Developmental changes of ketamine action against epileptic afterdischarges induced by hippocampal stimulation in rats
Language English Country Netherlands Media print
Document type Journal Article
PubMed
7805275
DOI
10.1016/0165-3806(94)90072-8
PII: 0165-3806(94)90072-8
Knihovny.cz E-resources
- MeSH
- Anticonvulsants pharmacology MeSH
- Behavior, Animal drug effects MeSH
- Electric Stimulation MeSH
- Electroencephalography drug effects MeSH
- Electrophysiology MeSH
- Epilepsy drug therapy physiopathology MeSH
- Hippocampus drug effects growth & development physiopathology MeSH
- Ketamine pharmacology MeSH
- Rats MeSH
- Disease Models, Animal MeSH
- Rats, Wistar MeSH
- Age Factors MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anticonvulsants MeSH
- Ketamine MeSH
Action of ketamine (5-40 mg/kg) was tested against electrically induced hippocampal afterdischarges (four stimulations in one session; 8 Hz, 15 s) in rats 7, 12, 18, 25 and 90 days old. In control sessions, there was either stable afterdischarge (AD) duration and wet dog shakes (WDS) number or there was an increase in ADs' duration with repeated stimulations. Ketamine had dose-dependent and age-dependent effects. In 7-18-day-old rats, ketamine suppressed better WDS number than AD duration, with nearly absent action on AD duration in 18-day-old animals. Ketamine was equipotent for both phenomena in 25-day-old rats and, in contrast, it decreased more AD duration than WDS number in 90-day-old rats. The data suggest a differentiation induced by ketamine in the expression of motor and electrographic phenomena of the experimental seizures.
References provided by Crossref.org
Age and activation determines the anticonvulsant effect of ifenprodil in rats
