Nootropní látky a jejich mechanismus úcinku ve vztahu k neuropatobiologii senilní demence. I. Poruchy neurotransmise v mozku
[Nootropic drugs and their action mechanisms in relation to the neuropathobiology of senile dementia. I. Neurotransmission disorders in the brain]
Language Czech Country Czech Republic Media print
Document type English Abstract, Journal Article, Review
PubMed
7987928
- MeSH
- Alzheimer Disease drug therapy physiopathology MeSH
- Dementia drug therapy pathology physiopathology MeSH
- Humans MeSH
- Brain physiopathology MeSH
- Synaptic Transmission * drug effects MeSH
- Nootropic Agents therapeutic use MeSH
- Check Tag
- Humans MeSH
- Publication type
- English Abstract MeSH
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Nootropic Agents MeSH
The author presents a review of agents which are presently included in the category of nootropic drugs and comments the relations between the pharmaceutical research of new nootropic and progressing knowledge of the neuropathobiology of Alzheimer's disease, senile dementia and degenerative processes of aging brain in general. In Part I., several hypotheses are discussed which explain the biological substrate of senile cognitive decline by disturbed brain synaptic neurotransmission (cholinergic, monoaminergic, petidergic) and, at the same time, drugs are suggested which may exert regulatory action on these dysfunctions.
