Enzymic and permeability activity of Pseudomonas aeruginosa after treatment with sub-MICs of organic ammonium salts
Language English Country United States Media print
Document type Journal Article
PubMed
7995601
DOI
10.1007/bf02814648
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Type C Phospholipases antagonists & inhibitors MeSH
- Protease Inhibitors pharmacology MeSH
- Capillary Permeability MeSH
- Quaternary Ammonium Compounds pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Pancreatic Elastase antagonists & inhibitors MeSH
- Pseudomonas aeruginosa drug effects enzymology pathogenicity MeSH
- Virulence MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Type C Phospholipases MeSH
- Protease Inhibitors MeSH
- Quaternary Ammonium Compounds MeSH
- Pancreatic Elastase MeSH
The effects of subinhibitory concentrations (1/4, 1/8, 1/16 of the MIC) of 12 organic ammonium salts of A (hard-alkyltrimethylammonium bromides) and B (soft--2-(dodecanoylamino)ethylalkyldimethylammonium bromides) homologous series on phospholipase C, proteinase, elastase and permeability activity were studied. The substances with longer substituents were more effective in reducing phospholipase C activity (hard and soft series) as well as proteinase (hard series). Phospholipase C was the most frequently and the most markedly inhibited enzyme. The organic ammonium salts were less effective in inhibiting elastase and permeability activity. Only one of the substances under study reduced all the tested activities.
See more in PubMed
J Antimicrob Chemother. 1987 May;19(5):569-78 PubMed
Antibiot Chemother (1971). 1989;42:42-9 PubMed
Rev Infect Dis. 1983 Sep-Oct;5(5):865-75 PubMed
Drugs Exp Clin Res. 1988;14(10):635-43 PubMed
Arzneimittelforschung. 1995 Feb;45(2):198-9 PubMed
Infect Immun. 1979 Aug;25(2):558-64 PubMed
Immunol Lett. 1991 Oct;30(2):201-5 PubMed
Infect Immun. 1982 Jun;36(3):1223-8 PubMed
Rev Infect Dis. 1983 Mar-Apr;5(2):279-313 PubMed
Folia Microbiol (Praha). 1993;38(4):349-52 PubMed
Folia Microbiol (Praha). 1980;25(4):347-53 PubMed
Antimicrob Agents Chemother. 1989 Jan;33(1):41-7 PubMed
Antimicrob Agents Chemother. 1985 Apr;27(4):468-72 PubMed
Antimicrob Agents Chemother. 1980 Jan;17(1):13-5 PubMed
Microbios. 1981;30(119):27-35 PubMed
Antibiot Chemother (1971). 1987;39:60-76 PubMed
J Antimicrob Chemother. 1987 May;19(5):579-83 PubMed
J Bacteriol. 1973 Oct;116(1):25-32 PubMed
Antimicrob Agents Chemother. 1993 Apr;37(4):675-80 PubMed
Infect Immun. 1988 Jul;56(7):1673-7 PubMed
Infect Immun. 1976 Sep;14(3):671-9 PubMed
Drug Metabol Drug Interact. 1989;7(1):29-51 PubMed
Drugs Exp Clin Res. 1992;18(10):415-22 PubMed
