Antimicrobial efficacy of quaternary bisammonium salts and the effect of their sub-MICs on Pseudomonas aeruginosa virulence factors
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
8919934
DOI
10.1007/bf02814209
Knihovny.cz E-zdroje
- MeSH
- algináty metabolismus MeSH
- antibakteriální látky chemie farmakologie MeSH
- fosfolipasy typu C antagonisté a inhibitory MeSH
- inhibitory enzymů chemie farmakologie MeSH
- inhibitory proteas chemie farmakologie MeSH
- kvartérní amoniové sloučeniny chemie farmakologie MeSH
- kyselina glukuronová MeSH
- kyseliny hexuronové MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- molekulární struktura MeSH
- pankreatická elastasa antagonisté a inhibitory MeSH
- Pseudomonas aeruginosa účinky léků metabolismus patogenita MeSH
- virulence účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- algináty MeSH
- antibakteriální látky MeSH
- fosfolipasy typu C MeSH
- inhibitory enzymů MeSH
- inhibitory proteas MeSH
- kvartérní amoniové sloučeniny MeSH
- kyselina glukuronová MeSH
- kyseliny hexuronové MeSH
- pankreatická elastasa MeSH
Antipseudomonadal activity of homologous series of six quaternary bisammonium salts (QBAS) (4,7-dioxo-3,8-dioxadekan-1,1-[bis(alkyldimethyldiammonium dibromide)] as well as the effect of their subinhibitory concentrations (sub-MICs) on Pseudomonas aeruginosa virulence factors was studied. Antibacterial activity of QBAS increased up to a certain length of the chain and then decreased with further elongation. All the tested sub-MICs of QBAS caused a significant suppression of phospholipase C activity (to 0-41%). Elastase and proteinase activity were less efficiently reduced. A more effective decrease of these activities was only found after treatment with one-fourth of the MICs of the tested substances. QBAS caused only an erratic decrease of alginate production.
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