Adaptive changes in fatty acids of E. coli strains exposed to a quaternary ammonium salt and an amine oxide
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17176754
DOI
10.1007/bf02931578
Knihovny.cz E-resources
- MeSH
- Drug Resistance, Bacterial MeSH
- Dimethylamines pharmacology MeSH
- Escherichia coli drug effects metabolism MeSH
- Adaptation, Physiological drug effects MeSH
- Quaternary Ammonium Compounds pharmacology MeSH
- Lipopolysaccharides metabolism MeSH
- Fatty Acids metabolism MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Dimethylamines MeSH
- Quaternary Ammonium Compounds MeSH
- Lipopolysaccharides MeSH
- Fatty Acids MeSH
- N-(1-methyldodecyl)-N,N,N-trimethylammonium MeSH Browser
- N,N-dimethyl-1-methyldodecylamine oxide MeSH Browser
Resistant strains of Escherichia coli were obtained by stepwise cultivation in media with increasing concentration of antimicrobially active 1-(methyldodecyl)dimethylamine oxide and 1-(methyldodecyl)trimethylammonium bromide. Adaptive changes were determined in the fatty-acid (FA) composition in an isolated lipopolysaccharide sample from the outer membrane of these strains. The composition of this FA mixture from adapted strains was compared with that of FA from a sensitive strain. The differences were found in level of palmitic, heptadecanoic, heptadecenoic, heptadecadienoic and nonadecenoic acids. In addition, the adapted strains differed from each other in the content of myristic, pentadecanoic, stearic and linoleic acids.
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