Antimicrobial efficacy of quaternary bisammonium salts and the effect of their sub-MICs on Pseudomonas aeruginosa virulence factors
Language English Country United States Media print
Document type Journal Article
PubMed
8919934
DOI
10.1007/bf02814209
Knihovny.cz E-resources
- MeSH
- Alginates metabolism MeSH
- Anti-Bacterial Agents chemistry pharmacology MeSH
- Type C Phospholipases antagonists & inhibitors MeSH
- Enzyme Inhibitors chemistry pharmacology MeSH
- Protease Inhibitors chemistry pharmacology MeSH
- Quaternary Ammonium Compounds chemistry pharmacology MeSH
- Glucuronic Acid MeSH
- Hexuronic Acids MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Molecular Structure MeSH
- Pancreatic Elastase antagonists & inhibitors MeSH
- Pseudomonas aeruginosa drug effects metabolism pathogenicity MeSH
- Virulence drug effects MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Alginates MeSH
- Anti-Bacterial Agents MeSH
- Type C Phospholipases MeSH
- Enzyme Inhibitors MeSH
- Protease Inhibitors MeSH
- Quaternary Ammonium Compounds MeSH
- Glucuronic Acid MeSH
- Hexuronic Acids MeSH
- Pancreatic Elastase MeSH
Antipseudomonadal activity of homologous series of six quaternary bisammonium salts (QBAS) (4,7-dioxo-3,8-dioxadekan-1,1-[bis(alkyldimethyldiammonium dibromide)] as well as the effect of their subinhibitory concentrations (sub-MICs) on Pseudomonas aeruginosa virulence factors was studied. Antibacterial activity of QBAS increased up to a certain length of the chain and then decreased with further elongation. All the tested sub-MICs of QBAS caused a significant suppression of phospholipase C activity (to 0-41%). Elastase and proteinase activity were less efficiently reduced. A more effective decrease of these activities was only found after treatment with one-fourth of the MICs of the tested substances. QBAS caused only an erratic decrease of alginate production.
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