Esters of omega-amino acids as flexible penetration enhancers
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8016177
Knihovny.cz E-resources
- MeSH
- Amino Acids chemistry pharmacology MeSH
- Diffusion MeSH
- Skin Absorption drug effects MeSH
- Humans MeSH
- Magnetic Resonance Spectroscopy MeSH
- Excipients MeSH
- In Vitro Techniques MeSH
- Theophylline pharmacokinetics MeSH
- Chromatography, High Pressure Liquid MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Amino Acids MeSH
- Excipients MeSH
- Theophylline MeSH
Series of esters of 6-aminohexanoic acid, 7-aminoheptanoic acid, and 8-aminooctanoic acid were synthesized as candidates for novel skin penetration enhancers. The permeation of theophylline expressed in the form of the enhancement factor (EF) was studied with human cadaver skin by a diffusion cell technique in the presence of the esters 1-17 in the water vehicle. The permeation in the presence of the 6-aminohexanoates 1-5 was also studied in the olive oil vehicle. Of the compounds tested, the most satisfactory enhancement in the water vehicle and oil vehicle were observed with octyl 6-aminohexanoate (EF = 45.5) and decyl 6-aminohexanoate (EF = 19.5), respectively.
