Akutní anikterická hepatitida s intrahepatální cholestázou vyvolaná podáváním prajmalium bitartarátu (Neo-Gilurytmal)
[Acute anicteric hepatitis and intrahepatic cholestasis caused by administration of prajmalium bitartrate (Neo-Gilurytmal)]
Language Czech Country Czech Republic Media print
Document type Case Reports, Journal Article
PubMed
8137378
- MeSH
- Acute Disease MeSH
- Cholestasis, Intrahepatic etiology MeSH
- Chemical and Drug Induced Liver Injury etiology MeSH
- Humans MeSH
- Prajmaline adverse effects MeSH
- Aged MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Names of Substances
- Prajmaline MeSH
The authors draw attention to a serious drug response to the derivative of the alkaloid ajmaline prajmalium (Neo-Gilurytmal, Giulini-GFR) which causes impairment of liver functions of various grades as a result of intrahepatic cholestasis. They draw attention to the necessity of a careful pharmacological case-history, evaluation of the premorbid stage, in particular former liver disease or contemporary administration of drugs which burden liver function (hormonal contraceptives, non-steroid antirheumatic drugs). It is essential to follow-up liver functions by laboratory tests already at the onset of treatment with Neo-Gilurytmal.
