- Keywords
- biologický poločas, esmolol, magnesium sulfuricum, vernakalant,
- MeSH
- Acetanilides administration & dosage pharmacology adverse effects MeSH
- Adenosine administration & dosage pharmacology adverse effects MeSH
- Amiodarone administration & dosage pharmacokinetics pharmacology adverse effects MeSH
- Anti-Arrhythmia Agents * administration & dosage pharmacokinetics pharmacology classification metabolism adverse effects MeSH
- Atropine administration & dosage pharmacokinetics pharmacology adverse effects MeSH
- Adrenergic beta-Antagonists administration & dosage pharmacokinetics pharmacology classification adverse effects MeSH
- Potassium Channel Blockers administration & dosage pharmacokinetics pharmacology classification adverse effects MeSH
- Calcium Channel Blockers administration & dosage pharmacokinetics pharmacology adverse effects MeSH
- Sodium Channel Blockers administration & dosage pharmacokinetics pharmacology classification adverse effects MeSH
- Dronedarone administration & dosage pharmacokinetics pharmacology adverse effects MeSH
- Phenytoin administration & dosage pharmacokinetics pharmacology adverse effects MeSH
- Cardiovascular Diseases * drug therapy MeSH
- Drug Interactions MeSH
- Humans MeSH
- Metoprolol administration & dosage pharmacokinetics pharmacology adverse effects MeSH
- Liver Diseases complications MeSH
- Kidney Diseases complications MeSH
- Drug-Related Side Effects and Adverse Reactions MeSH
- Prajmaline administration & dosage pharmacokinetics pharmacology adverse effects MeSH
- Propafenone administration & dosage pharmacokinetics pharmacology adverse effects MeSH
- Sotalol administration & dosage pharmacokinetics pharmacology adverse effects MeSH
- Verapamil administration & dosage pharmacokinetics pharmacology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Případ je prezentovaný na 17-ročnej študentke, ktorá požila doma váčšie množstvo tabliet a kapsúl. Požila perorálne antiarytmika Katen a Neo-Gilurytmal, bez klinickej terapie uvedenými liekmi a bez historie suicidálneho pokusu. Bezprostřednou příčinou smrti bolo udusenie vdýchnutím zvratkov zo žalúdočného obsahu po požití nadměrného množstva liekov. Ako yedf^ší nález pri pitve bol zistený opuch mozgu, krvné výronky na seróznych blánách a prekrvenie dutiny brušnej. Toxikologickou postmortálnou analýzou krvi, pečené, obličky, žalúdočného a črevného obsahu bola stanovená noxa. Mexiletin a prajmalin boli stanovené kapilárnou plynovou chromatografiou s detekciou FID. Retenčný čas mexiletinu bol 6,66 minut a prajmahnu 15.15 minut. Koncentrácia alkoholu v krvi 0,21 mg.g-1 Koncentrácia mexiletinu v krvi 0,001 mg.g'^' V žalúdočnom obsahu prajmalin 3,03 mg.g^ a mexiletin 0,11 mg.g-1
The case is presented on 17-year-old student who ingested larger doses of tablets and capsules in privacy. She ingested antiarhythmics Katen and Neo-Gilurytmal without clinical therapy by these drugs and without history of suicidal attempt. The imminent case of death was asphyxiation by aspiration of vomits from gastric contents after ingestion of excessive doses of drugs. The secondary findings as brain edema, petechiae under the serous membranes and congestion of the abdominal cavity, were releaved at autopsy. Noxae was identified by the postmortem toxicological analysis of blood, liver, kidney, gastric contents and intestinal contents. Mexiletine and prajmaline were analysed by the capillary gas chromatography with FID detection. Retention time of mexiletiitine was 6.66 minutes, prajmaline 15.15 minutes, respectively. Blood alcohol concentraion was 0.21 mg.g-1" Concentration of prajmaline in gastric contents was 3.03 mg.g\ mexiletine 0.11 'ng.g-1, respectively.
- Keywords
- NEO-GILURYTMAL, KATEN,
- MeSH
- Anti-Arrhythmia Agents toxicity MeSH
- Humans MeSH
- Mexiletine analysis toxicity MeSH
- Adolescent MeSH
- Drug-Related Side Effects and Adverse Reactions MeSH
- Poisoning etiology mortality MeSH
- Prajmaline analysis toxicity MeSH
- Death etiology MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- Keywords
- NEO-GILURYTMAN (GIULINI PHARMA, SRN,
- MeSH
- Adult MeSH
- Cholestasis, Intrahepatic chemically induced MeSH
- Chemical and Drug Induced Liver Injury etiology MeSH
- Humans MeSH
- Prajmaline adverse effects MeSH
- Arrhythmias, Cardiac drug therapy complications MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
