Perinatal hypoxia suppresses immune response of adult rats
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
8180153
Knihovny.cz E-resources
- MeSH
- Erythrocytes immunology MeSH
- Phagocytosis physiology MeSH
- Fetal Hypoxia immunology MeSH
- Hypoxia immunology MeSH
- Immune Tolerance MeSH
- Rats MeSH
- Neutrophils physiology MeSH
- Animals, Newborn immunology MeSH
- Ovalbumin immunology MeSH
- Sheep MeSH
- Macrophages, Peritoneal physiology MeSH
- Rats, Wistar MeSH
- Pregnancy, Animal immunology MeSH
- Pregnancy MeSH
- Prenatal Exposure Delayed Effects MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Ovalbumin MeSH
We tested the effect of perinatal (one week prenatal and one week postnatal) normobaric hypoxia on the immune response of rats in their 9th week of life. We found that perinatally hypoxic rats produced less serum antibodies after sequential immunization with ovalbumin and sheep red blood cells. Also phagocytosis of HEMA microparticles by neutrophil leukocytes from perinatally hypoxic rats was depressed as well as the oxidative burst of their peritoneal macrophages and neutrophils. These results demonstrate that perinatal hypoxia has an important effect on the immune system of the rat.
