31P magnetic resonance spectroscopy investigation of skeletal muscle metabolism in uraemic patients
Jazyk angličtina Země Švýcarsko Médium print
Typ dokumentu klinické zkoušky, časopisecké články
PubMed
8247184
DOI
10.1159/000187478
Knihovny.cz E-zdroje
- MeSH
- adenosintrifosfát metabolismus MeSH
- chronické selhání ledvin metabolismus moč MeSH
- dospělí MeSH
- energetický metabolismus MeSH
- fosfáty metabolismus MeSH
- fosfokreatin metabolismus MeSH
- fosfor MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční spektroskopie MeSH
- svaly metabolismus MeSH
- uremie metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- Názvy látek
- adenosintrifosfát MeSH
- fosfáty MeSH
- fosfokreatin MeSH
- fosfor MeSH
Using the method of in vivo magnetic resonance spectroscopy we examined 17 patients with moderately advanced chronic renal insufficiency, 21 patients with chronic renal failure treated by haemodialysis, and 15 dialyzed patients with symptomatic renal osteopathy. The ratios of intracellular phosphocreatine and inorganic phosphate concentrations of these subjects measured at rest were compared with those found in healthy controls. While we noted significantly lower (p < 0.01) ratio values in all patients, subjects with osteopathy showed a lower value than dialyzed patients free of bone disease. Haemodialysis improved the result of examination in 7 patients. The results can be summarized as follows: (1) patients with altered renal function have significantly impaired energy metabolism of skeletal muscle, and (2) the disorder is more severe in patients with renal osteopathy than in those free of it.
Citace poskytuje Crossref.org
MR compatible ergometers for dynamic 31P MRS
