The role of the kidney in the development of hypertension: a transplantation study in the Prague hypertensive rat
Jazyk angličtina Země Německo Médium print
Typ dokumentu časopisecké články
PubMed
8309780
DOI
10.1007/bf00374168
Knihovny.cz E-zdroje
- MeSH
- hypertenze genetika patofyziologie MeSH
- inbrední kmeny potkanů MeSH
- krevní tlak fyziologie MeSH
- krysa rodu Rattus MeSH
- ledviny fyziologie MeSH
- nefrektomie MeSH
- novorozená zvířata MeSH
- transplantace ledvin fyziologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
It has been shown that genetic hypertension in rats usually "travels with the kidney". To elucidate the mechanism of this phenomenon further, experiments were carried out in the Prague hypertensive (PH) rat, a model of genetic hypertension derived from the Wistar strain, in which a normotensive parallel, the Prague normotensive (PN) rat, was also bred from the same parent pair. Thus, it is possible to transfer organs between both parallels without substantial signs of rejection and without the use of immunosuppressive drugs. Unilateral nephrectomy and transplantation of one kidney between PH and PN rats, did not affect the arterial blood pressure (BP). Transplantation of one kidney from PN rats to bilaterally nephrectomised PH rats normalised the high BP. If a PH rat was left with one original kidney in situ after the transplantation of a "normotensive" kidney, the high BP persisted until the original "hypertensive" kidney was removed. This removal resulted in sustained normalisation of BP. When the development of high BP in the PH rats was prevented for 2 months after weaning by antihypertensive drugs, transplantation of kidneys from these rats to bilaterally nephrectomised PN rats always induced a sustained hypertension in the recipient. These results argue against a role of high-BP-induced damage to the kidney and against an intrinsic increase in the salt-reabsorptive capacity of the tubular epithelium in PH rats. The data support the view that the kidney from PH rats produces a "hypertensinogenic" substance, the secretion of which is genetically determined and is not influenced by the magnitude of the BP.
Zobrazit více v PubMed
Am J Physiol. 1992 Jun;262(6 Pt 2):H1809-17 PubMed
Clin Exp Hypertens A. 1990;12(6):957-1002 PubMed
Am J Physiol. 1990 Mar;258(3 Pt 2):F606-11 PubMed
Hypertension. 1990 Apr;15(4):436-42 PubMed
Clin Exp Hypertens. 1993 Sep;15(5):807-18 PubMed
Circ Res. 1974 Jan;34(1):94-101 PubMed
Circ Res. 1975 Jun;36(6):692-6 PubMed
Br Med J (Clin Res Ed). 1986 Apr 19;292(6527):1041-4 PubMed
Jpn Heart J. 1978 Nov;19(6):886-94 PubMed
Hypertension. 1992 Jan;19(1 Suppl):I2-8 PubMed
Clin Sci Mol Med. 1974 Nov;47(5):435-48 PubMed
Surgery. 1967 May;61(5):771-3 PubMed
Research on Experimental Hypertension in Prague (1966-2009)
