Properties of melanosomes and their exploitation in the diagnosis and treatment of melanoma
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, přehledy
PubMed
8400855
Knihovny.cz E-zdroje
- MeSH
- imunotoxiny terapeutické užití MeSH
- lidé MeSH
- melaniny biosyntéza metabolismus MeSH
- melanocyty metabolismus MeSH
- melanom diagnóza metabolismus terapie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- imunotoxiny MeSH
- melaniny MeSH
Melanosomes are subcellular organelles with unique properties: they are producers and scavengers of cytotoxic quinones and are involved in free radical reactions. They behave as energy absorbing and converting devices, have an ion-exchange capacity and show affinity to a variety of substances. Even in the absence of melanin, premelanosomes show characteristic properties due to the presence of specific proteins. The melanosome concentration in pigment tissues is high enough to offer possibilities for influencing pigment cells and for detecting and/or killing melanoma cells. The exploitation of melanosome properties in practice is reviewed.
