A survey of the Czechoslovak follow-up of lung cancer mortality in uranium miners
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- dospělí MeSH
- hornictví * MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory plic epidemiologie etiologie mortalita MeSH
- nádory vyvolané zářením epidemiologie etiologie mortalita MeSH
- následné studie MeSH
- pracovní expozice * MeSH
- radon * MeSH
- senioři MeSH
- uran * MeSH
- vztah dávky záření a odpovědi MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Československo epidemiologie MeSH
- Názvy látek
- radon * MeSH
- uran * MeSH
The major Czechoslovak cohort of uranium miners (S-cohort) is surveyed in terms of diagrams illustrating dependences on calendar year, age, and exposure to radon and radon progeny. An analysis of the dose dependence of lung cancer mortality is performed by nonparametric and, subsequently, by parametric methods. In the first step, two-dimensional isotonic regression is employed to derive the lung cancer mortality rate and the relative excess risk as functions of age attained and of lagged cumulated exposure. In a second step, analytical fits in terms of relative risk models are derived. The treatment is largely analogous to the methods applied by the BEIR IV Committee to other major cohorts of uranium miners. There is a marked dependence of the excess risk on age attained and on time since exposure. A specific characteristic of the Czechoslovak data is the nonlinearity of the dependence of the lung cancer excess risk on the cumulated exposure; exposures on the order of 100 working level months or less appear to be more effective per working level month than larger exposures but, in the absence of an internal control group, this cannot be excluded to be due to confounders such as smoking or environmental exposures. A further notable observation is the association of larger excess risks with longer protraction of the exposures.
Citace poskytuje Crossref.org
Recent results from the study of West Bohemian uranium miners exposed to radon and its progeny
Mortality in uranium miners in west Bohemia: a long-term cohort study