Mapping of endogenous lectins in macrophages colonizing an implanted polymer surface--effect of polymer structure
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8562790
DOI
10.1016/0142-9612(95)93578-2
PII: 0142961295935782
Knihovny.cz E-resources
- MeSH
- Biocompatible Materials chemistry pharmacology MeSH
- Dermatologic Surgical Procedures MeSH
- Phenotype MeSH
- Galactose metabolism MeSH
- Glycoproteins metabolism MeSH
- Histocytochemistry MeSH
- Rats MeSH
- N-Acetylneuraminic Acid MeSH
- Sialic Acids metabolism MeSH
- Lectins metabolism MeSH
- Macrophages cytology drug effects enzymology metabolism MeSH
- Giant Cells metabolism MeSH
- Polystyrenes chemistry pharmacology MeSH
- Rats, Wistar MeSH
- Foreign-Body Reaction pathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biocompatible Materials MeSH
- Galactose MeSH
- Glycoproteins MeSH
- N-Acetylneuraminic Acid MeSH
- Sialic Acids MeSH
- Lectins MeSH
- Polystyrenes MeSH
The design of synthetic polymers may affect structural features of inflammatory cells, for example the expression of endogenous sugar receptor molecules like lectins in macrophages and foreign body giant multinucleate cells. This characteristic was studied histochemically by use of biotinylated (neo)glycoproteins. The results demonstrate the influence of polymer structure on the phenotypic expression of molecules recognizing carbohydrates in these cells. Very strong activity was observed for carrier-immobilized beta-galactose in cells colonizing hydrophobic polystyrene implants. Sialic acid moieties were not recognized by cells located on the surface of all types of polymeric implant. This study encourages investigation of the influence of polymer design on the differentiation of macrophages.
References provided by Crossref.org
