Natural killer cell activity in coeliac disease: effect of in vitro treatment on effector lymphocytes and/or target lymphoblastoid, myeloid and epithelial cell lines with gliadin
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8768253
DOI
10.1007/bf02818518
Knihovny.cz E-resources
- MeSH
- Antibody-Dependent Cell Cytotoxicity drug effects MeSH
- Killer Cells, Natural drug effects immunology MeSH
- Celiac Disease immunology MeSH
- Cytotoxicity, Immunologic drug effects MeSH
- Child MeSH
- Adult MeSH
- Gliadin pharmacology MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Lymphocytes drug effects MeSH
- Tumor Cells, Cultured MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Gliadin MeSH
To analyze the possible involvement of natural killer (NK) cell activity in the pathogenetic mechanism of coeliac disease (CD) we measured the spontaneous cytotoxic cell activity of peripheral blood mononuclear cells (PMNC) from patients with CD and from healthy donors. No significant differences were found between the NK cell activity of PMNC from healthy donors and from patients with CD using a standard 51 Cr release assay. However, a 30-min treatment of PMNC with gliadin inhibited NK cell activity in patients with CD. On the other hand, a 1-d incubation with gliadin induced cytotoxic cell activity of PMNC against the NK-resistant target cells such as the epithelial HT-29 and the lymphoblastoid RAJI cell lines, suggesting that activation of PMNC by cultivation with gliadin can occur.
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