Reduction in virulence of Naegleria fowleri following growth with cholesterol
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
8774777
Knihovny.cz E-resources
- MeSH
- Cholesterol pharmacology MeSH
- Mice MeSH
- Naegleria fowleri drug effects growth & development pathogenicity MeSH
- Virulence MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Names of Substances
- Cholesterol MeSH
It has been reported that the virulence of axenically cultivated Entamoeba histolytica increases following growth with cholesterol. The purpose of this study was to determine whether cholesterol would enhance the virulence of axenically cultivated Naegleria fowleri. Amoebae were cultivated in axenic medium with (100 micrograms/ml) or without cholesterol for 6 months and tested in mice for changes in virulence. After 6 months of continuous cultivation. N. fowleri grown with cholesterol was less virulent for mice than the same strain grown without cholesterol.
