Future research directions to characterize environmental mutagens in highly polluted area
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.
PubMed
8781390
PubMed Central
PMC1469653
DOI
10.1289/ehp.104-1469653
Knihovny.cz E-zdroje
- MeSH
- adukty DNA genetika MeSH
- antioxidancia terapeutické užití MeSH
- biologické markery * MeSH
- chromozomální aberace MeSH
- fyziologická adaptace MeSH
- karcinogeny životního prostředí analýza MeSH
- lidé MeSH
- monitorování životního prostředí metody MeSH
- mutace MeSH
- nádory chemicky indukované prevence a kontrola MeSH
- oprava DNA MeSH
- předpověď MeSH
- rizikové faktory MeSH
- vystavení vlivu životního prostředí * škodlivé účinky MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Názvy látek
- adukty DNA MeSH
- antioxidancia MeSH
- biologické markery * MeSH
- karcinogeny životního prostředí MeSH
Population monitoring using methods of molecular epidemiology combined with reliable data on exposure is an extremely powerful approach to determine the effect of mutagens on human populations. Although human blood and urine have traditionally been used for biomonitoring, an increase in the use of placental and buccal smear samples should be expected. As biomarkers of exposure, DNA strand breaks and hemoglobin and albumin adducts seem to be most sensitive. As biomarkers of response, cytogenetic analysis determining chromosome aberrations or micronuclei has been widely used Additional information can be obtained by using the chromosome painting technique and by determining gene mutations at the hprt locus: however, epidemiological studies exhibiting a relationship between these biomarkers and environmental pollution are still lacking. The use of sperm to analyze the effect of environmental mutagens in germ cells (e.g, sperm morphology and sperm aneuploidy) should be encouraged. The determination of susceptibility by analyzing genetic polymorphism, which is responsible for individual differences in the biotransformation of mutagens and carcinogens, will gain importance for risk assessment. Future research should include validating molecular methods, studying adaptive response to chemical carcinogens, and studying the modulatory effect of antioxidants, as well as the effect of carcinogens on immunity.
Zobrazit více v PubMed
Carcinogenesis. 1990 Jul;11(7):1229-31 PubMed
Environ Health Perspect. 1996 May;104 Suppl 3:679-82 PubMed
Prog Clin Biol Res. 1986;209B:327-35 PubMed
Mutat Res. 1988 Mar;204(3):379-406 PubMed
Mutat Res. 1991 Mar;247(1):103-11 PubMed
Annu Rev Genet. 1990;24:305-26 PubMed
Mutat Res. 1991 Jul;263(3):133-6 PubMed
Mutat Res. 1991 Sep-Oct;250(1-2):299-306 PubMed
Nature. 1992 Nov 19;360(6401):256-8 PubMed
Int J Radiat Biol. 1993 Jul;64(1):27-37 PubMed
Carcinogenesis. 1993 Sep;14(9):1733-5 PubMed
Cancer Epidemiol Biomarkers Prev. 1993 Nov-Dec;2(6):581-5 PubMed
Mutat Res. 1994 Jan 16;304(2):285-94 PubMed
Mutat Res. 1994 Feb;317(1):25-42 PubMed
Mutat Res. 1994 May;321(3):175-85 PubMed
Carcinogenesis. 1994 May;15(5):813-5 PubMed
Clin Chem. 1994 Jul;40(7 Pt 2):1438-43 PubMed
Carcinogenesis. 1994 Jun;15(6):1271-4 PubMed
Carcinogenesis. 1994 Jul;15(7):1405-11 PubMed
Mutat Res. 1994 Aug;316(2):91-102 PubMed
Mutagenesis. 1994 May;9(3):269-72 PubMed
Mutat Res. 1994 Oct-Dec;313(2-3):117-29 PubMed
Mutat Res. 1994 Oct-Dec;313(2-3):249-62 PubMed
Mutat Res. 1995 Jan;336(1):69-77 PubMed
Epidemiology. 1995 Mar;6(2):190-4 PubMed
Mutat Res. 1995 Apr;346(4):195-202 PubMed
Carcinogenesis. 1995 May;16(5):1037-46 PubMed
Carcinogenesis. 1995 Jun;16(6):1305-9 PubMed
Mutat Res. 1995 Aug;330(1-2):13-21 PubMed
Environ Health Perspect. 1995 May;103(5):466-70 PubMed
Mutat Res. 1995 Oct;338(1-6):129-39 PubMed
Epidemiology. 1995 Jul;6(4):455-7 PubMed
Environ Health Perspect. 1996 May;104 Suppl 3:445-8 PubMed
Mutat Res. 1983 May;120(2-3):181-6 PubMed
