Protein profiling of the myocardium exposed to pressure overload from birth
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8789328
Knihovny.cz E-resources
- MeSH
- Aorta surgery MeSH
- Collagen analysis MeSH
- Rats MeSH
- Myosin Light Chains analysis MeSH
- Myocardium chemistry MeSH
- Animals, Newborn MeSH
- Rats, Wistar MeSH
- Sarcoplasmic Reticulum chemistry MeSH
- Heart physiopathology MeSH
- Pressure MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Collagen MeSH
- Myosin Light Chains MeSH
Aortic banding induced in 2-day-old (A2) and 6-day-old (A6) male rats increased the left ventricular (LV) weight after 60 days; right ventricular (RV) enlargement occurred in the A2 group only. The concentration of collagenous proteins in the LV was elevated in both experimental groups (more in the A2 rats) at the expenses of sarcoplasmic proteins. Aortic banding also affected the proportion of collagen types (lower collagen I, higher collagen III, V) and myosin light chains (higher LC1/LC2) in the LV. Similar changes of proteins in the RV were less pronounced.
Cardiac phosphocreatine deficiency induced by GPA during postnatal development in rat
