Subinhibitory concentrations of organic ammonium salts: the effect on biological properties of Salmonella typhimurium
Language English Country United States Media print
Document type Journal Article
PubMed
8851560
DOI
10.1007/bf02815414
Knihovny.cz E-resources
- MeSH
- Virus Activation drug effects MeSH
- Chlorocebus aethiops MeSH
- Salmonella Phages drug effects MeSH
- Capillary Permeability drug effects MeSH
- Rabbits MeSH
- Skin blood supply drug effects MeSH
- Quaternary Ammonium Compounds chemistry pharmacology MeSH
- Molecular Structure MeSH
- Salmonella typhimurium drug effects pathogenicity virology MeSH
- Vero Cells MeSH
- Structure-Activity Relationship MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Quaternary Ammonium Compounds MeSH
The effect of subinhibitory concentrations (subMICs) of new organic ammonium salts of four homologous series of alkylammonium bromides (32 compounds) was determined with respect to the induction of lysogenic strain prophage, influence of permeability reactions in a rabbit skin test and cytotoxic changes of monolayers of Vero cells. The culture filtrates were prepared by 1-d cultivation of Salmonella typhimurium in a synthetic culture medium under conditions of intensive aeration at 37 degrees C after addition of subinhibitory concentrations of organic ammonium salts. The results showed that substances of the homologous series of 2-(10-undecenoyloxy)ethyl-alkyldimethylammonium bromides were characterized by a prophage-inducing effect in lysogenic strain cells. The induction of prophage raised with rising concentrations of subMICs of the substances, and its titer in the culture filtrates was mostly 4.10(6) PFU/mL. Substances C3, C9 and C12 of the same homologous series had the strongest effect on the permeability reaction in rabbit skin in 1/2 MICs. One-half MICs of four substances (B14, C3, C12, C14) and 1/4 MICs of substance A16 influenced cytotoxic changes on Vero cells, the other substances were ineffective.
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