Muscle NMDA receptors regulate the resting membrane potential through NO-synthase
Language English Country Czech Republic Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8869279
Knihovny.cz E-resources
- MeSH
- 2-Amino-5-phosphonovalerate pharmacology MeSH
- Diaphragm physiology MeSH
- Muscle Denervation MeSH
- Rats MeSH
- Glutamic Acid pharmacology MeSH
- Membrane Potentials physiology MeSH
- N-Methylaspartate pharmacology MeSH
- NG-Nitroarginine Methyl Ester pharmacology MeSH
- Rats, Wistar MeSH
- Receptors, N-Methyl-D-Aspartate physiology MeSH
- Muscles innervation metabolism physiology MeSH
- Nitric Oxide Synthase antagonists & inhibitors physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- 2-Amino-5-phosphonovalerate MeSH
- Glutamic Acid MeSH
- N-Methylaspartate MeSH
- NG-Nitroarginine Methyl Ester MeSH
- Receptors, N-Methyl-D-Aspartate MeSH
- Nitric Oxide Synthase MeSH
The early postdenervation depolarization of rat diaphragm muscle fibres (8-10 mV) is substantially smaller (3 mV) when muscle strips are bathed with 1 mM L-glutamate (GLU) or N-methyl-D-aspartate (NMDA). The effects of GLU and NMDA are not seen in the presence of aminophosphonovaleric acid (APV), a blocker of NMDA-subtype of glutamate receptors, 5 mM Mg2+ (which blocks NMDA-controlled ion channels) and L-nitroarginine methylester (NAME), an inhibitor of NO-synthase. This indicates that NMDA-subtype of GLU receptors might be involved in the regulation of the membrane potential in muscle fibres, most probably through the NO-synthase system.
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