Resting non-quantal acetylcholine (ACh) and probably glutamate (Glu) release from nerve endings activates M1- and NMDA receptor-mediated Ca2+ entry into the sarcoplasm with following activation of NOS and production of NO. This is a trophic message from motoneurons, which keeps the Cl- transport inactive in the innervated sarcolemma. After denervation, the secretion of ACh and Glu at the neuromuscular junction is eliminated within 3-4 h and the production of NO in the sarcoplasm is lowered. As a result, the Cl- influx is probably activated by dephosphorylation of the Cl- transporter with subsequent elevation of intracellular Cl- concentration. The equilibrium Cl- potential becomes more positive and the muscle membrane becomes depolarized.

Institute of Physiology Academy of Sciences of the Czech Republic Vídenská 1083 Prague Czech Republic

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Proc Natl Acad Sci U S A. 1988 Sep;85(17):6556-60 PubMed

Brain Res. 1982 Mar 11;235(2):378-86 PubMed

Am J Physiol. 1977 Mar;232(3):C109-14 PubMed

J Pharmacol Exp Ther. 1963 Oct;142:21-3 PubMed

Pflugers Arch. 1987 Aug;409(4-5):540-6 PubMed

Nature. 1987 Aug 13-19;328(6131):640-3 PubMed

Nature. 1984 Apr 19-25;308(5961):736-8 PubMed

Prog Neurobiol. 1983;21(3):135-98 PubMed

FASEB J. 1992 Feb 1;6(3):845-52 PubMed

Mol Chem Neuropathol. 1998 Apr;33(3):163-74 PubMed

Fiziol Zh SSSR Im I M Sechenova. 1987 Jan;73(1):51-5 PubMed

J Physiol. 1982 May;326:285-96 PubMed

J Physiol. 1978 Mar;276:67-82 PubMed

Br J Pharmacol. 1994 Jun;112(2):557-65 PubMed

Comp Biochem Physiol. 1967 Dec;23(3):729-48 PubMed

Pflugers Arch. 1977 Oct 19;371(1-2):3-8 PubMed

J Physiol. 1979 Jan;286:1-14 PubMed

J Physiol. 1994 Jun 15;477 ( Pt 3):497-502 PubMed

Cell Tissue Res. 1998 Jan;291(1):57-63 PubMed

Neirofiziologiia. 1991;23(5):625-8 PubMed

Microsc Res Tech. 2001 Nov 1;55(3):148-53 PubMed

Synapse. 1991 Mar;7(3):207-15 PubMed

Neurosci Lett. 1988 Nov 11;93(2-3):204-8 PubMed

J Physiol. 1989 Aug;415:329-50 PubMed

Neurosci Behav Physiol. 2001 Jul-Aug;31(4):451-5 PubMed

Sb Lek. 1999;100(1):27-31 PubMed

Physiol Rev. 2001 Jan;81(1):209-237 PubMed

Exp Physiol. 1996 May;81(3):341-8 PubMed

Pflugers Arch. 1995 Mar;429(5):716-21 PubMed

Int Rev Neurobiol. 1992;34:283-384 PubMed

J Physiol. 1975 Dec;253(1):53-77 PubMed

Trends Neurosci. 1992 Mar;15(3):108-13 PubMed

Proc R Soc Lond B Biol Sci. 1977 Feb 11;196(1122):59-72 PubMed

J Neurosci. 1994 Oct;14(10):5844-57 PubMed

J Physiol. 1986 Apr;373:97-114 PubMed

Trends Pharmacol Sci. 1989 Mar;10(3):110-4 PubMed

Neirofiziologiia. 1987;19(6):766-71 PubMed

Br J Pharmacol. 1989 May;97(1):65-70 PubMed

Physiol Res. 1995;44(3):205-8 PubMed

Proc Natl Acad Sci U S A. 1985 May;82(10):3514-8 PubMed

Anat Embryol (Berl). 1993 Nov;188(5):501-13 PubMed

Pflugers Arch. 1971;328(1):36-50 PubMed

Neuron. 1993 Jul;11(1):133-43 PubMed

Neuroreport. 1997 Jan 20;8(2):403-6 PubMed

Br J Pharmacol. 1991 Dec;104(4):1024-32 PubMed

Eur J Pharmacol. 1996 Dec 5;316(2-3):219-22 PubMed

J Physiol. 1990 Oct;429:429-49 PubMed

Arch Biochem Biophys. 1996 Jul 1;331(1):41-7 PubMed

Pflugers Arch. 1979 May 15;380(1):101-4 PubMed

J Neurosci. 1990 Sep;10(9):3178-82 PubMed

Microsc Res Tech. 2001 Nov 1;55(3):181-6 PubMed

Neurosci Res. 1999 Feb;33(2):81-6 PubMed

Biull Eksp Biol Med. 1989 Nov;108(11):563-6 PubMed

Proc Natl Acad Sci U S A. 1988 May;85(9):3175-9 PubMed

J Neurochem. 2003 Apr;85(1):206-13 PubMed

Nature. 1984 Apr 19-25;308(5961):734-6 PubMed

J Mol Cell Cardiol. 1994 Nov;26(11):1487-95 PubMed

Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8 PubMed

Eur J Neurosci. 2000 Mar;12(3):980-6 PubMed

J Physiol. 1990 Apr;423:631-40 PubMed

Eur J Pharmacol. 1991 Jul 9;199(3):379-81 PubMed

Pflugers Arch. 1977 Sep 16;370(3):295-7 PubMed

Eur J Neurosci. 2001 Jun;13(11):2047-53 PubMed

Neuroscience. 1995 Feb;64(4):847-50 PubMed

Rozhl Chir. 1996 May;75(5):237-9 PubMed

Neuroreport. 1993 Feb;4(2):151-4 PubMed

Physiol Res. 1999;48(4):315-7 PubMed

J Physiol. 1986 Apr;373:481-511 PubMed

Neuroreport. 1993 Dec 13;5(3):337-40 PubMed

Nature. 1987 Feb 5-11;325(6104):529-31 PubMed

J Physiol. 1983 Jan;334:461-74 PubMed

Neuroscience. 1983 Jun;9(2):429-35 PubMed

J Physiol. 1976 Mar;255(3):651-67 PubMed

Annu Rev Physiol. 1976;38:177-216 PubMed

Neurosci Res. 2000 Aug;37(4):255-63 PubMed

Science. 1987 May 1;236(4801):589-93 PubMed

Pflugers Arch. 1982 Aug;394(2):161-4 PubMed

J Physiol Paris. 1995;89(3):157-62 PubMed

From Frog Muscle to Brain Neurons: Joys and Sorrows in Neuroscience