Hybrid sterility in the mouse
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review
Grant support
IRO1 D28395 01 A1
PHS HHS - United States
PubMed
8909138
DOI
10.1016/0168-9525(96)10040-8
PII: 0168-9525(96)10040-8
Knihovny.cz E-resources
- MeSH
- X Chromosome * MeSH
- Fertility genetics MeSH
- Hybridization, Genetic MeSH
- Humans MeSH
- Chromosome Mapping MeSH
- Meiosis MeSH
- Models, Genetic * MeSH
- Muridae genetics MeSH
- Infertility, Male genetics MeSH
- Mice genetics MeSH
- Spermatogenesis genetics MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Mice genetics MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
The sterility of hybrids between various mouse species follows Haldane's rule by affecting only the males. Hitherto, five hybrid sterility (Hst) loci have been identified in the mouse genome. Haldane's rule holds also for chromosomal sterility in all studied mammalian species, including man. The males heterozygous for various male-sterile chromosomal rearrangements show the same meiotic phenotype: partially asynaptic, rearranged autosomes associate with the X Chromosome. Thus, the X-Chromosome inactivation in the male meiosis might function as a checkpoint leading to the meiotic arrest in sterile hybrids. Chromosomal and gene hybrid sterility might be interrelated because the attributes of chromosomal sterility, such as X-autosome associations, occur also in interspecies hybrids with genic sterility.
Trends Genet 1997 Jan;13(1):42 PubMed
References provided by Crossref.org
Chromosome-wide characterization of meiotic noncrossovers (gene conversions) in mouse hybrids
Prdm9 Intersubspecific Interactions in Hybrid Male Sterility of House Mouse
Genomic Structure of Hstx2 Modifier of Prdm9-Dependent Hybrid Male Sterility in Mice
Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice
Hybrid Sterility Locus on Chromosome X Controls Meiotic Recombination Rate in Mouse
X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids
Mechanistic basis of infertility of mouse intersubspecific hybrids
Interallelic and intergenic incompatibilities of the Prdm9 (Hst1) gene in mouse hybrid sterility
Chromosomal rearrangement interferes with meiotic X chromosome inactivation
Genetic analysis of X-linked hybrid sterility in the house mouse
