Modulation of Prdm9-controlled meiotic chromosome asynapsis overrides hybrid sterility in mice
Jazyk angličtina Země Velká Británie, Anglie Médium electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
29537370
PubMed Central
PMC5902161
DOI
10.7554/elife.34282
PII: 34282
Knihovny.cz E-zdroje
- Klíčová slova
- Prdm9, chromosomes, evolutionary biology, gene expression, genomics, homology-dependent meiotic chromosome pairing, mouse, speciation, synaptonemal complex,
- MeSH
- biologická evoluce * MeSH
- chiméra genetika MeSH
- chromozomy genetika MeSH
- dvouřetězcové zlomy DNA MeSH
- histonlysin-N-methyltransferasa genetika MeSH
- hybridizace genetická MeSH
- infertilita genetika MeSH
- meióza genetika MeSH
- mužská infertilita genetika MeSH
- myši MeSH
- párování chromozomů genetika MeSH
- rekombinace genetická MeSH
- reprodukční izolace MeSH
- synaptonemální komplex genetika MeSH
- vznik druhů (genetika) MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- histonlysin-N-methyltransferasa MeSH
- prdm9 protein, mouse MeSH Prohlížeč
Hybrid sterility is one of the reproductive isolation mechanisms leading to speciation. Prdm9, the only known vertebrate hybrid-sterility gene, causes failure of meiotic chromosome synapsis and infertility in male hybrids that are the offspring of two mouse subspecies. Within species, Prdm9 determines the sites of programmed DNA double-strand breaks (DSBs) and meiotic recombination hotspots. To investigate the relation between Prdm9-controlled meiotic arrest and asynapsis, we inserted random stretches of consubspecific homology on several autosomal pairs in sterile hybrids, and analyzed their ability to form synaptonemal complexes and to rescue male fertility. Twenty-seven or more megabases of consubspecific (belonging to the same subspecies) homology fully restored synapsis in a given autosomal pair, and we predicted that two or more DSBs within symmetric hotspots per chromosome are necessary for successful meiosis. We hypothesize that impaired recombination between evolutionarily diverged chromosomes could function as one of the mechanisms of hybrid sterility occurring in various sexually reproducing species.
Faculty of Science Charles University Prague Czech Republic
Institute of Molecular Genetics Academy of Sciences of the Czech Republic Vestec Czech Republic
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Genic and chromosomal components of Prdm9-driven hybrid male sterility in mice (Mus musculus)
Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility
Chromosome-wide characterization of meiotic noncrossovers (gene conversions) in mouse hybrids
Prdm9 Intersubspecific Interactions in Hybrid Male Sterility of House Mouse
Genomic Structure of Hstx2 Modifier of Prdm9-Dependent Hybrid Male Sterility in Mice