Influence of cadmium on resistance to antibiotics in salmonellae isolated from pigs
Language English Country United States Media print
Document type Journal Article
PubMed
8919933
DOI
10.1007/bf02814207
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Drug Resistance, Microbial * genetics MeSH
- Escherichia coli drug effects genetics MeSH
- Cadmium pharmacology MeSH
- Conjugation, Genetic MeSH
- Lactams MeSH
- Drug Resistance, Multiple genetics MeSH
- Swine MeSH
- R Factors genetics MeSH
- Salmonella drug effects genetics isolation & purification MeSH
- Streptomycin pharmacology MeSH
- In Vitro Techniques MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Cadmium MeSH
- Lactams MeSH
- Streptomycin MeSH
Repeated cultivations (4 passages) of salmonellae (18 strains) resistant to cadmium, streptomycin and beta-lactam antibiotics in Müller-Hinton Broth (MHB) and Mac-Conkey Broth (MCB) without and with CdSO4 (2, 20 and 100 mg/L) showed a higher toxic effect of cadmium in MCB. The strains survived at CdSO4 100 mg/L in MHB for four transfers, in MCB only a single transfer. In dependence on the medium used and amount of metal added, the increase of resistance to antibiotics was different. In MHB, the same levels of resistance to carbenicillin and streptomycin were induced by CdSO4 (20 and 100 mg/L), in MCB it was by 2 and 20 mg/L. Simultaneous stop of the growth of a control culture S. typhimurium with chromosomal resistance to streptomycin, isolates with and without plasmid in MCB which contained CdSO4 100 mg/L, and the results of conjugal transfer of resistance suggest that changes of resistance to antibiotics were not mediated by determinants of resistance to antibiotics. The binding of cadmium to outer membrane protein can cause a decreased permeability to these antibiotics as a resistance mechanism.
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Appl Environ Microbiol. 1990 May;56(5):1485-91 PubMed
J Clin Microbiol. 1991 Feb;29(2):398-400 PubMed
J Bacteriol. 1992 Dec;174(24):8102-10 PubMed
Appl Environ Microbiol. 1992 Dec;58(12):3868-72 PubMed
J Clin Microbiol. 1993 Sep;31(9):2366-70 PubMed
Appl Environ Microbiol. 1989 Sep;55(9):2287-92 PubMed
Sci Total Environ. 1980 Jan;14(1):5-17 PubMed
Appl Environ Microbiol. 1985 Oct;50(4):930-3 PubMed
Plasmid. 1992 Jan;27(1):17-28 PubMed
Antimicrob Agents Chemother. 1977 Oct;12(4):545-7 PubMed
Microbiol Rev. 1983 Sep;47(3):361-409 PubMed
Folia Microbiol (Praha). 1994;39(1):74-8 PubMed
J Clin Microbiol. 1991 Apr;29(4):827-9 PubMed
J Bacteriol. 1975 Mar;121(3):1180-8 PubMed
Appl Environ Microbiol. 1984 May;47(5):1012-6 PubMed
Ann N Y Acad Sci. 1981;368:23-59 PubMed
J Antimicrob Chemother. 1991 Dec;28(6):877-85 PubMed
J Appl Bacteriol. 1993 Aug;75(2):108-12 PubMed
Science. 1986 Nov 21;234(4779):964-9 PubMed
Appl Environ Microbiol. 1989 Aug;55(8):2101-2104 PubMed
Appl Environ Microbiol. 1979 May;37(5):859-61 PubMed
Antimicrob Agents Chemother. 1980 Mar;17(3):428-33 PubMed
Science. 1984 Sep 7;225(4666):1043-6 PubMed
Rev Infect Dis. 1986 Mar-Apr;8(2):189-207 PubMed
Appl Environ Microbiol. 1993 Sep;59(9):2851-6 PubMed
