Biological activity of new aza analogues of quinolones
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
9246761
DOI
10.1007/bf02818977
Knihovny.cz E-resources
- MeSH
- Anti-Infective Agents chemistry pharmacology MeSH
- Aza Compounds chemistry pharmacology MeSH
- Quinolones chemistry pharmacology MeSH
- Enterobacteriaceae drug effects MeSH
- Euglena gracilis drug effects MeSH
- Nalidixic Acid pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Plastids drug effects MeSH
- Plasmids drug effects MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Anti-Infective Agents MeSH
- Aza Compounds MeSH
- Quinolones MeSH
- Nalidixic Acid MeSH
A series of novel derivatives of 4H-pyrido[1,2-]pyrimidine, 1,4-dihydro-4-oxo-1,5-naphthyridine and 1,4-dihydro-4-oxo-1,6-naphthyridine were prepared and their biological activity was compared with that of nalidixic acid. The in vitro antibacterial activity of the tested compounds was lower than that of nalidixic acid except for two agents, 1b and 2c, with a higher activity against Enterococcus faecalis. The compounds were tested for their ability to cure four plasmids from two species of Enterobacteriaceae. The derivatives eliminated three plasmids (pKM101, pBR322, F'lac) at one-half or one-quarter of the minimal inhibitory concentration. Plasmid RP4 was unaffected by the treatment. None of these compounds showed better antichloroplast activity than nalidixic acid.
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