Hydrogels in endovascular embolization. VI. Toxicity tests of poly(2-hydroxyethyl methacrylate) particles on cell cultures
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
9363335
DOI
10.1016/s0142-9612(97)00059-8
PII: S0142961297000598
Knihovny.cz E-resources
- MeSH
- Biocompatible Materials toxicity MeSH
- Cell Division drug effects MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Polyhydroxyethyl Methacrylate toxicity MeSH
- Drug Evaluation, Preclinical MeSH
- Embolization, Therapeutic methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Biocompatible Materials MeSH
- Polyhydroxyethyl Methacrylate MeSH
Cytotoxicity of poly(2-hydroxyethyl methacrylate) [poly(HEMA)] hydrogel spherical particles, prepared by radical suspension polymerization and designed for endovascular occlusion, was studied in vitro on cell cultures. Testing methods included a direct contact test and extraction test. No inhibition of growth of cells surrounding the poly(HEMA) beads and a very low inhibition of cell viability, only in concentrated extracts in long-term contact, were observed. As a result, poly(HEMA) beads can be considered non-toxic.
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