Influence of the postantibiotic effect and postantibiotic sub-MICs effect of netilmicin, tobramycin, ciprofloxacin and pefloxacin on alginate production by Pseudomonas aeruginosa
Language English Country United States Media print
Document type Comparative Study, Journal Article
PubMed
9449771
DOI
10.1007/bf02814621
Knihovny.cz E-resources
- MeSH
- Alginates metabolism MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Anti-Infective Agents pharmacology MeSH
- Depression, Chemical MeSH
- Ciprofloxacin administration & dosage pharmacology MeSH
- Gentamicins administration & dosage pharmacology MeSH
- Cross Infection microbiology MeSH
- Glucuronic Acid MeSH
- Hexuronic Acids MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Netilmicin administration & dosage pharmacology MeSH
- Pefloxacin administration & dosage pharmacology MeSH
- Pseudomonas Infections microbiology MeSH
- Pseudomonas aeruginosa drug effects isolation & purification metabolism pathogenicity MeSH
- Tobramycin administration & dosage pharmacology MeSH
- Virulence drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Alginates MeSH
- Anti-Bacterial Agents MeSH
- Anti-Infective Agents MeSH
- Ciprofloxacin MeSH
- Gentamicins MeSH
- Glucuronic Acid MeSH
- Hexuronic Acids MeSH
- Netilmicin MeSH
- Pefloxacin MeSH
- Tobramycin MeSH
The postantibiotic effect (PAE) (postantibiotic phase induced by 2x or 4x MIC) as well as the postantibiotic effect of subinhibitory concentrations (0.1x, 0.2x and 0.3x MIC) (PA SME) of netilmicin, tobramycin, ciprofloxacin and pefloxacin affected the production of the virulence factor alginate by a P. aeruginosa strain. Aminoglycosides and ciprofloxacin at a concentration of 4x MIC inhibited the alginate production more significantly than 2x MIC. Suprainhibitory concentrations of aminoglycosides were more effective than pefloxacin (2x or 4x MIC) and ciprofloxacin (2x MIC). PA SME demonstrated by the above antibiotics (with the exception of ciprofloxacin 2x MIC + 0.1x MIC) suppressed alginate production more efficiently.
See more in PubMed
Lancet. 1988 Jun 18;1(8599):1359-61 PubMed
J Antimicrob Chemother. 1981 Nov;8 Suppl C:81-91 PubMed
J Antimicrob Chemother. 1990 Jul;26(1):29-38 PubMed
Zentralbl Bakteriol. 1996 Mar;283(3):322-7 PubMed
Rev Infect Dis. 1981 Jan-Feb;3(1):28-37 PubMed
Scand J Infect Dis Suppl. 1989;58:1-55 PubMed
Chemotherapy. 1993 May-Jun;39(3):153-62 PubMed
Chemotherapy. 1991;37(2):114-21 PubMed
J Antimicrob Chemother. 1993 Oct;32(4):519-37 PubMed
Chemotherapy. 1992;38(6):388-94 PubMed
J Antimicrob Chemother. 1993 May;31 Suppl D:159-66 PubMed
Anal Biochem. 1968 Sep;24(3):470-81 PubMed
J Antimicrob Chemother. 1994 Dec;34(6):921-30 PubMed
Can J Microbiol. 1985 Apr;31(4):387-92 PubMed
Anal Biochem. 1962 Oct;4:330-4 PubMed
New Microbiol. 1993 Jul;16(3):275-9 PubMed
J Infect Dis. 1977 Feb;135(2):217-23 PubMed
J Antimicrob Chemother. 1993 Jun;31(6):881-92 PubMed
Antibiot Chemother (1971). 1989;42:72-9 PubMed
Folia Microbiol (Praha). 1996;41(1):39-42 PubMed
Folia Microbiol (Praha). 1996;41(1):61-4 PubMed
Antimicrob Agents Chemother. 1993 Oct;37(10):2200-5 PubMed
J Antimicrob Chemother. 1995 Jul;36(1):231-6 PubMed
