Inhibition of Pseudomonas aeruginosa alginate expression by subinhibitory concentrations of antibiotics
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
9090826
DOI
10.1007/bf02816342
Knihovny.cz E-zdroje
- MeSH
- algináty metabolismus MeSH
- aminoglykosidy MeSH
- antibakteriální látky farmakologie MeSH
- chinolony farmakologie MeSH
- laktamy MeSH
- makrolidy MeSH
- mikrobiální testy citlivosti MeSH
- Pseudomonas aeruginosa účinky léků metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- algináty MeSH
- aminoglykosidy MeSH
- antibakteriální látky MeSH
- chinolony MeSH
- laktamy MeSH
- makrolidy MeSH
The effects of subinhibitory concentrations (1/4, 1/8, 1/16 of the MIC) of quinolones (ciprofloxacin, enoxacin, nalidixic acid, norfloxacin, ofloxacin, pefloxacin), aminoglycosides (amikacin, gentamicin, netilmicin, streptomycin, tobramycin), beta-lactams (aztreonam, ceftazidime, imipenem, ticarcilin) and macrolides (erythromycin, roxitromycin) on the excretion of alginate by a P. aeruginosa strain were studied. Both beta-lactam and macrolide antibiotics were found ineffective at the concentrations tested, except erythromycin and imipenem at 1/4 MIC. Aminoglycosides at a concentration of 1/4 MIC reduced most effectively the excretion of alginate. Quinolones were also effective at this sub-MIC; 1/16 MIC was ineffective with all antibiotics or stimulated the production of alginate.
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