Postantibiotic effects of imipenem and enoxacin against S. typhimurium and S. enteritidis and the influence on their surface hydrophobicity
Language English Country United States Media print
Document type Journal Article
PubMed
9569634
DOI
10.1007/bf02815553
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Enoxacin pharmacology MeSH
- Imipenem pharmacology MeSH
- Surface Properties drug effects MeSH
- Salmonella enteritidis drug effects MeSH
- Salmonella typhimurium drug effects MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Enoxacin MeSH
- Imipenem MeSH
The influence of the postantibiotic effect (PAE) and the postantibiotic sub-MICs effect (PA SME) of imipenem and enoxacin on the surface hydrophobicity of S. typhimurium and S. enteritidis strains were studied by evaluating Congo red binding and the aggregation in molar solutions of ammonium sulfate (SAT). A PAE was induced by 2x and 4 x MIC of antibiotics tested for 0.5 h. Suprainhibitory concentrations of imipenem against S. typhimurium induced a short PAE (0.3-0.6 h) compared to S. enteritidis (6.0-9.7 h). Suprasubinhibitory concentrations of imipenem did not allow a regrowth of S. enteritidis. Similar results were also found for enoxacin. Evaluation of surface hydrophobic properties of the salmonellas after affecting both PAEs and PA SMEs has shown that imipenem at concentrations 4 x MIC and 4 x MIC + 0.3 x MIC partially influenced the hydrophobicity of S. typhimurium. S. enteritidis was more susceptible toward both antibiotics tested.
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