Relationships between the chemical structure of antimycobacterial substances and their activity against atypical strains. Part 14: 3-Aryl-6,8-dihalogeno-2H-1,3-benzoxazine-2,4(3H)-diones
Language English Country Germany Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
9507695
DOI
10.1002/(sici)1521-4184(199801)331:1<3::aid-ardp3>3.0.co;2-2
PII: 10.1002/(SICI)1521-4184(199801)331:1<3::AID-ARDP3>3.0.CO;2-2
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents chemical synthesis pharmacology MeSH
- Antitubercular Agents chemical synthesis pharmacology MeSH
- Hydrocarbons, Halogenated chemical synthesis pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Mycobacterium drug effects MeSH
- Oxazines chemical synthesis pharmacology MeSH
- Spectrophotometry, Infrared MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Antitubercular Agents MeSH
- Hydrocarbons, Halogenated MeSH
- Oxazines MeSH
A set of eight derivatives of 6,8-dichloro-3-phenyl-2H-benzoxazine-2,4(3H)-dione and nine derivatives of 6,8-dibromo-3-phenyl-2H-1, 3-benzoxazine-2,4(3H)-dione, substituted on the phenyl ring, was prepared by the reaction of the corresponding salicylanilides with ethyl chloroformate. The compounds were evaluated in vitro for antimycobacterial activity against Mycobacterium tuberculosis, Mycobacterium kansasii, and Mycobacterium avium. Their activity increases with increasing hydrophobicity and electron-withdrawing ability of the substituents on the phenyl ring.
References provided by Crossref.org
Antimycobacterial activity of basic ethyl esters of alkoxy-substituted phenylcarbamic acids
In vitro antifungal activity of 3-phenyl-2H-benzoxazine-2,4(3H)-diones
