Antimycobacterial activity of basic ethyl esters of alkoxy-substituted phenylcarbamic acids
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
12744075
DOI
10.1007/bf02931274
Knihovny.cz E-resources
- MeSH
- Antitubercular Agents pharmacology MeSH
- Esters MeSH
- Carbamates chemical synthesis chemistry pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Mycobacterium avium drug effects MeSH
- Mycobacterium kansasii drug effects MeSH
- Mycobacterium tuberculosis drug effects MeSH
- Mycobacterium drug effects MeSH
- Structure-Activity Relationship MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antitubercular Agents MeSH
- Esters MeSH
- Carbamates MeSH
- phenylcarbamic acid MeSH Browser
A series of 124 basic ethyl esters of alkoxy-substituted phenylcarbamic acids with the alkoxy group in position 2, 3 or 4 on the phenyl ring, and basic substituents attached to the ethyl moiety in position 2, were evaluated for in vitro antimycobacterial activity against strains of Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium. In vitro antimycobacterial activity becomes higher with increasing hydrophobic properties of the alkoxy groups. The p- and m-substituted derivatives were more active than the o-substituted ones. Direct relationship between the structure of the basic substituents and the activity was not found.
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