• This record comes from PubMed

Antimycobacterial activity of basic ethyl esters of alkoxy-substituted phenylcarbamic acids

. 2003 ; 48 (1) : 45-50.

Language English Country United States Media print

Document type Journal Article, Research Support, Non-U.S. Gov't

A series of 124 basic ethyl esters of alkoxy-substituted phenylcarbamic acids with the alkoxy group in position 2, 3 or 4 on the phenyl ring, and basic substituents attached to the ethyl moiety in position 2, were evaluated for in vitro antimycobacterial activity against strains of Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium. In vitro antimycobacterial activity becomes higher with increasing hydrophobic properties of the alkoxy groups. The p- and m-substituted derivatives were more active than the o-substituted ones. Direct relationship between the structure of the basic substituents and the activity was not found.

See more in PubMed

Farmaco. 1999 Oct 30;54(10):666-72 PubMed

Eur J Med Chem. 2000 Jul-Aug;35(7-8):733-41 PubMed

Cesk Farm. 1976 May;25(3-4):118-21 PubMed

Arch Pharm (Weinheim). 1998 Jan;331(1):3-6 PubMed

Pharmazie. 2000 Nov;55(11):858-9 PubMed

J Med Chem. 1971 Feb;14(2):148-52 PubMed

Ceska Slov Farm. 2002 May;51(3):140-4 PubMed

Cesk Farm. 1993 Apr;42(2):88-91 PubMed

Pharmazie. 1987 Oct;42(10):702-3 PubMed

Pharmazie. 1978 Aug;33(8):509-12 PubMed

Farmaco. 2000 Nov-Dec;55(11-12):725-9 PubMed

Pharmazie. 1986 Oct;41(10):744-5 PubMed

Folia Microbiol (Praha). 2002;47(5):488-92 PubMed

Newest 20 citations...

See more in
Medvik | PubMed

Dibasic Derivatives of Phenylcarbamic Acid against Mycobacterial Strains: Old Drugs and New Tricks?

. 2018 Sep 28 ; 23 (10) : . [epub] 20180928

Synthesis and In Vitro Antimycobacterial Activity of Novel N-Arylpiperazines Containing an Ethane-1,2-diyl Connecting Chain

. 2017 Nov 30 ; 22 (12) : . [epub] 20171130

Synthesis and biological evaluation of 2-hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(alkoxycarbonyl)amino]benzoates

. 2013 ; 2013 () : 274570. [epub] 20131029

New antimycobacterial 2,3-dihydro-1-alkylindole-2-thiones

. 2006 ; 51 (1) : 25-6.

QSAR study of antimycobacterial activity of quaternary ammonium salts of piperidinylethyl esters of alkoxysubstituted phenylcarbamic acids

. 2006 ; 51 (1) : 21-4.

1-Aryl-5-benzylsulfanyltetrazoles, a new group of antimycobacterial compounds against potentially pathogenic strains

. 2005 ; 50 (3) : 195-7.

New antimycobacterial S-alkylisothiosemicarbazones

. 2005 ; 50 (6) : 479-81.

A new group of potential antituberculotics: hydrochlorides of piperidinylalkyl esters of alkoxy-substituted phenylcarbamic acids

. 2004 ; 49 (3) : 265-8.

Antimycobacterial activity of piperidinylpropyl esters of alkoxy-substituted phenylcarbamic acids

. 2003 ; 48 (5) : 585-7.

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...