1-Aryl-5-benzylsulfanyltetrazoles, a new group of antimycobacterial compounds against potentially pathogenic strains
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
16295656
DOI
10.1007/bf02931565
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents chemistry pharmacology MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Mycobacterium avium drug effects pathogenicity MeSH
- Mycobacterium kansasii drug effects pathogenicity MeSH
- In Vitro Techniques MeSH
- Tetrazoles chemistry pharmacology MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- Tetrazoles MeSH
A set of 21 1-phenyl-5-benzylsulfanyltetrazoles substituted on the phenyl ring as well as on the benzyl moiety was evaluated for in vitro antimycobacterial activity against Mycobacterium avium and two strains of M. kansasii. We tried to use the Hansch approach, the Free-Wilson approach and their combination for structure-activity correlation but the calculations were statistically insignificant.
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