From Morris Water Maze to computer tests in the prediction of Alzheimer's disease
Jazyk angličtina Země Švýcarsko Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
22205134
DOI
10.1159/000333121
PII: 000333121
Knihovny.cz E-zdroje
- MeSH
- Alzheimerova nemoc komplikace diagnóza MeSH
- bludiště - učení fyziologie MeSH
- diagnóza počítačová metody MeSH
- kognitivní poruchy komplikace diagnóza MeSH
- lidé MeSH
- neuropsychologické testy MeSH
- progrese nemoci MeSH
- psychiatrické posuzovací škály MeSH
- regresní analýza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- vnímání prostoru fyziologie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: Spatial navigation performance in the Hidden Goal Task (HGT), a real-space human analogue of the Morris Water Maze, can identify amnestic mild cognitive impairment (aMCI) patients with memory impairment of the hippocampal type, a known indicator of incipient Alzheimer's disease (AD). OBJECTIVE: Contrast results from computer versus real-space versions of the HGT. METHODS: A total of 42 aMCI patients were clinically and neuropsychologically classified into: (1) memory impairment of the hippocampal type--the hippocampal aMCI (HaMCI; n = 10) and (2) isolated retrieval impairment--the nonhippocampal aMCI (NHaMCI; n = 32). Results were compared to the control (n = 28) and AD (n = 21) groups. RESULTS: The HaMCI group, although similar to the NHaMCI group with respect to overall cognitive impairment, performed poorer on the computer version of the HGT and yielded parallel results to the real-space version. The two versions were strongly correlated. CONCLUSIONS: Both versions of the HGT can reliably identify aMCI with pronounced memory impairment of the hippocampal type. The computer version of the HGT may be a useful, relatively inexpensive screening tool for early detection of individuals at a high risk of AD.
Citace poskytuje Crossref.org
Spatial navigation questionnaires as a supportive diagnostic tool in early Alzheimer's disease
The Combined Effect of APOE and BDNF Val66Met Polymorphisms on Spatial Navigation in Older Adults
Spatial navigation in young versus older adults
Spatial navigation-a unique window into physiological and pathological aging