Diffusion heterogeneity and anisotropy in rat hippocampus
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Anisotropy MeSH
- Axons physiology MeSH
- Corpus Callosum physiology MeSH
- Diffusion MeSH
- Extracellular Space physiology MeSH
- Hippocampus physiology MeSH
- Iontophoresis instrumentation methods MeSH
- Rats MeSH
- Quaternary Ammonium Compounds pharmacokinetics MeSH
- Nerve Fibers physiology MeSH
- Rats, Wistar MeSH
- Pyramidal Cells physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Quaternary Ammonium Compounds MeSH
- tetramethylammonium MeSH Browser
We provide evidence for anisotropic diffusion in rat corpus callosum and hippocampus. The preferential diffusion pathway in corpus callosum is along the myelinated axon fibres; in the hippocampus diffusion is easier along the transversal axis (x) than along the sagittal (y) or vertical (z) axes. In all areas studied, i.e. in the cortex, corpus callosum and hippocampus, the mean ECS volume fraction alpha (alpha = ECS volume/total tissue volume) ranged between 0.20 and 0.22 and mean non-specific uptake k' was between 4.0 and 5.9 x 10(-3) s-1. Diffusional anisotropy in the hippocampus may be of importance for extrasynaptic transmission and in the 'cross-talk' between synapses.
References provided by Crossref.org
Astrocytes and extracellular matrix in extrasynaptic volume transmission
Diffusion in brain extracellular space
