Qualitative changes of anticonvulsant action of felbamate during development in rats
Language English Country Netherlands Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
9661966
DOI
10.1016/s0387-7604(98)00030-8
PII: S0387760498000308
Knihovny.cz E-resources
- MeSH
- Anticonvulsants therapeutic use MeSH
- Felbamate MeSH
- Phenylcarbamates MeSH
- Convulsants MeSH
- Rats MeSH
- Animals, Newborn growth & development physiology MeSH
- Pentylenetetrazole MeSH
- Rats, Wistar MeSH
- Propylene Glycols therapeutic use MeSH
- Aging physiology MeSH
- Dose-Response Relationship, Drug MeSH
- Seizures chemically induced drug therapy MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anticonvulsants MeSH
- Felbamate MeSH
- Phenylcarbamates MeSH
- Convulsants MeSH
- Pentylenetetrazole MeSH
- Propylene Glycols MeSH
The anticonvulsant action of felbamate (25, 50, 100 and 150 mg/kg i.p.) was tested against motor seizures induced by pentylenetetrazol in five age-groups of rats (7, 12, 18, 25 and 90 days old). In adult rats, felbamate suppressed generalized tonic-clonic seizures leaving intact minimal clonic seizures. In all groups of rat pups felbamate exhibited a specific action against the tonic phase of generalized tonic-clonic seizures. In addition, the highest dose of felbamate was found to suppress minimal seizures in 18-day-old rats. The changes of felbamate action during ontogeny might be due to multiple mechanisms of anticonvulsant action with an uneven developmental profile.
References provided by Crossref.org
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
