Cytotoxic necrotizing factor 1 from Escherichia coli: a toxin with a new intracellular activity for eukaryotic cells
Language English Country United States Media print
Document type Journal Article, Review
PubMed
9717256
DOI
10.1007/bf02818614
Knihovny.cz E-resources
- MeSH
- Bacterial Toxins metabolism toxicity MeSH
- Cytoskeleton metabolism microbiology MeSH
- Cytotoxins metabolism toxicity MeSH
- Escherichia coli chemistry metabolism MeSH
- Eukaryotic Cells metabolism microbiology MeSH
- Humans MeSH
- GTP-Binding Proteins metabolism MeSH
- Escherichia coli Proteins * MeSH
- rho GTP-Binding Proteins MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Bacterial Toxins MeSH
- cytotoxic necrotizing factor type 1 MeSH Browser
- Cytotoxins MeSH
- GTP-Binding Proteins MeSH
- Escherichia coli Proteins * MeSH
- rho GTP-Binding Proteins MeSH
Certain pathogenic Escherichia coli strains elaborate a toxin, the cytotoxic necrotizing factor type 1 (CNF1). CNF1 covalently and specifically modifies the p21 Rho GTP-binding protein in mammalian cells by deamidation of the p21 Rho glutamine 63. CNF1 modification of Rho leads to permanent activation of the GTP-binding protein by blocking intrinsic and RhoGAP GTPase activities. Rho activation by CNF1 induces reorganization of the actin cytoskeleton into large stress fibers and the multiplication of focal contact points. Deamidation is a new catalytic activity described for an intracellularly acting toxin.
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