Erratic behavior of nitric oxide within the immune system: illustrative review of conflicting data and their immunopharmacological aspects
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
9756129
DOI
10.1016/s0192-0561(98)00036-8
PII: S0192056198000368
Knihovny.cz E-resources
- MeSH
- Apoptosis MeSH
- Arginine metabolism MeSH
- Autoimmune Diseases metabolism MeSH
- Cytokines physiology MeSH
- Cytotoxicity, Immunologic drug effects MeSH
- Nitric Oxide Donors pharmacology MeSH
- Species Specificity MeSH
- Encephalomyelitis, Autoimmune, Experimental metabolism MeSH
- Endotoxemia metabolism MeSH
- Inflammatory Bowel Diseases metabolism MeSH
- Immune System drug effects physiology MeSH
- Infections metabolism MeSH
- Isoenzymes antagonists & inhibitors metabolism MeSH
- Rats MeSH
- Humans MeSH
- Histocompatibility Antigens Class II biosynthesis immunology MeSH
- Mice MeSH
- Neoplasms blood supply metabolism prevention & control therapy MeSH
- Nitric Oxide pharmacology physiology MeSH
- Nitric Oxide Synthase antagonists & inhibitors metabolism MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Arginine MeSH
- Cytokines MeSH
- Nitric Oxide Donors MeSH
- Isoenzymes MeSH
- Histocompatibility Antigens Class II MeSH
- Nitric Oxide MeSH
- Nitric Oxide Synthase MeSH
The literature data assembled in this article document the variation of immunobiological effects of nitric oxide (NO). A number of factors are obviously responsible for the diversity, ranging from inactivity, alleviation, but not rarely to exacerbation of certain pathogenetic processes. A better understanding of NO interactions with the immune system can only be reached if more complex experimental designs to study the effects of reactive nitrogen species are adopted in the future. They should integrate major participating variables and take into account pharmacodynamic/kinetic aspects of NO production in triggering the ultimate effects. If manipulation of NO in the organism by means of recently developed NO inhibitors and NO donors is to become a rational tool of immunopharmacological strategies, detailed knowledge of their pharmacologies and toxicologies is urgently needed in order to differentiate between the effects of NO and other side effects. Hopefully, this approach could improve the predictability of the clinical outcomes of NO manipulation.
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