HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články
- MeSH
- biopsie MeSH
- dospělí MeSH
- dysplazie děložního hrdla patologie virologie MeSH
- genotyp MeSH
- lidé MeSH
- mladiství MeSH
- nádory děložního čípku patologie virologie MeSH
- Papillomaviridae klasifikace MeSH
- vakcinace * MeSH
- vakcíny proti papilomavirům imunologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- vakcíny proti papilomavirům MeSH
HPV-vaccinated women develop CIN III very rarely. We have identified a study group of 38 such patients and showed that a specific HPV genotype prevalence in those cases equals the prevalence of HPV genotypes in CIN III present in the general Czech population. In all cases, CIN III was diagnosed within 3 years after having completed the HPV vaccination. We conclude that dysplasia was present before the vaccination in those women. A history of abnormal pre-vaccination PAP smear result (present in 78 % of women in the study group) and age of over 17 by the time of vaccination completion (97 % of women in the study group) are identified as probable factors increasing the risk of CIN III development after HPV vaccination.
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