HPV typing of high-grade dysplasia (CIN III) in cone biopsies of 38 HPV-vaccinated women
Language English Country Germany Media print-electronic
Document type Journal Article
- MeSH
- Biopsy MeSH
- Adult MeSH
- Uterine Cervical Dysplasia pathology virology MeSH
- Genotype MeSH
- Humans MeSH
- Adolescent MeSH
- Uterine Cervical Neoplasms pathology virology MeSH
- Papillomaviridae classification MeSH
- Vaccination * MeSH
- Papillomavirus Vaccines immunology MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Papillomavirus Vaccines MeSH
HPV-vaccinated women develop CIN III very rarely. We have identified a study group of 38 such patients and showed that a specific HPV genotype prevalence in those cases equals the prevalence of HPV genotypes in CIN III present in the general Czech population. In all cases, CIN III was diagnosed within 3 years after having completed the HPV vaccination. We conclude that dysplasia was present before the vaccination in those women. A history of abnormal pre-vaccination PAP smear result (present in 78 % of women in the study group) and age of over 17 by the time of vaccination completion (97 % of women in the study group) are identified as probable factors increasing the risk of CIN III development after HPV vaccination.
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