Type I beta-lactamases of Enterobacter cloacae and resistance to beta-lactam antibiotics
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
10069013
DOI
10.1007/bf02816390
Knihovny.cz E-resources
- MeSH
- Anti-Bacterial Agents pharmacology MeSH
- Genes, Bacterial physiology MeSH
- beta-Lactamases genetics pharmacology MeSH
- Cephamycins pharmacology MeSH
- Cefoxitin pharmacology MeSH
- Enterobacter cloacae drug effects enzymology genetics MeSH
- beta-Lactamase Inhibitors MeSH
- Enzyme Inhibitors pharmacology MeSH
- Carbenicillin pharmacology MeSH
- Cloxacillin pharmacology MeSH
- Clavulanic Acid pharmacology MeSH
- p-Chloromercuribenzoic Acid pharmacology MeSH
- Microbial Sensitivity Tests MeSH
- Penicillins pharmacology MeSH
- Plasmids MeSH
- Penicillin Resistance * MeSH
- Sulbactam pharmacology MeSH
- Sulfhydryl Reagents pharmacology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Bacterial Agents MeSH
- beta-Lactamases MeSH
- Cephamycins MeSH
- Cefoxitin MeSH
- beta-Lactamase Inhibitors MeSH
- Enzyme Inhibitors MeSH
- Carbenicillin MeSH
- Cloxacillin MeSH
- Clavulanic Acid MeSH
- p-Chloromercuribenzoic Acid MeSH
- Penicillins MeSH
- Sulbactam MeSH
- Sulfhydryl Reagents MeSH
The interaction of type-I beta-lactamases from Enterobacter cloacae with diverse beta-lactam compounds was examined. The ability of penicillin and cefoxitin to induce beta-lactamase production in this strain was assessed. The effect of beta-lactamase inhibitors was measured on beta-lactamase extracts and on intact cells. E. cloacae 78 strain is a stably derepressed mutant showing limited susceptibility to a number of antibiotics except imipenem. Imipenem would therefore be the appropriate choice for therapy of infections caused by stably derepressed mutants of Enterobacter sp. producing type-I beta-lactamases.
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