Myoepitheliomas of the skin and soft tissues. Report of 12 cases
Language English Country Germany Media print
Document type Case Reports, Comparative Study, Journal Article
PubMed
10389622
DOI
10.1007/s004280050358
Knihovny.cz E-resources
- MeSH
- Adult MeSH
- Immunohistochemistry MeSH
- Keratins analysis MeSH
- Middle Aged MeSH
- Humans MeSH
- Myoepithelioma chemistry pathology MeSH
- Skin Neoplasms chemistry pathology MeSH
- Soft Tissue Neoplasms chemistry pathology MeSH
- S100 Proteins analysis MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Comparative Study MeSH
- Names of Substances
- Keratins MeSH
- S100 Proteins MeSH
We describe 12 cutaneous and soft tissue myoepitheliomas, most of them in elderly patients. Morphologically the cutaneous and soft tissue myoepitheliomas revealed the same spectrum as their salivary gland counterparts. They were composed of a mixture of spindle, epithelioid and clear myoepithelial cells. Immunohistochemically they were positive to keratins and S-100 protein and reacted inconsistently with antibodies to smooth muscle actin. Morphologically they lacked any folliculo-sebaceous or apocrine differentiation. We believe that they are related to the eccrine type of cutaneous mixed tumours. Most cases had a benign behaviour, but 1 tumour metastasized, and the patient died of the tumour. Myoepitheliomas of soft tissues should be distinguished from other neoplasms with epithelial differentiation and from ossifying fibromyxoid tumour of soft parts, parachordoma and extraskeletal myxoid chondrosarcoma.
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