GPI-microdomains: a role in signalling via immunoreceptors
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
10431155
DOI
10.1016/s0167-5699(99)01489-9
PII: S0167-5699(99)01489-9
Knihovny.cz E-resources
- MeSH
- Models, Biological MeSH
- Cell Membrane immunology MeSH
- Glycosylphosphatidylinositols immunology MeSH
- Leukocytes immunology MeSH
- Humans MeSH
- Membrane Proteins immunology MeSH
- Receptors, Immunologic metabolism MeSH
- Signal Transduction immunology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Glycosylphosphatidylinositols MeSH
- Membrane Proteins MeSH
- Receptors, Immunologic MeSH
Glycosylphosphatidylinositol (GPI)-anchored proteins and glycosphingolipids are assembled on the leukocyte surface within membrane microdomains, which also accommodate a set of cytoplasmic signalling molecules (Src family kinases, G-proteins, linker proteins). Recent results suggest that these membrane specializations mediate not only signal transduction via GPI-proteins and glycolipids but also play important roles in initiation of signalling via immunoreceptors.
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