Inhibition of NO synthase activity in nervous tissue leads to decreased motor activity in the rat
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
10805416
Knihovny.cz E-zdroje
- MeSH
- inhibitory enzymů farmakologie MeSH
- krysa rodu Rattus MeSH
- mícha účinky léků enzymologie fyziologie MeSH
- mozeček enzymologie MeSH
- mozek účinky léků enzymologie fyziologie MeSH
- mozková kůra enzymologie MeSH
- NG-nitroargininmethylester farmakologie MeSH
- pohybová aktivita účinky léků MeSH
- potkani Wistar MeSH
- synthasa oxidu dusnatého antagonisté a inhibitory metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- inhibitory enzymů MeSH
- NG-nitroargininmethylester MeSH
- synthasa oxidu dusnatého MeSH
The nitric oxide/cGMP system has been shown to play a crucial role in the mechanism of learning and memory. The aim of the present study was to investigate whether the inhibition of NO synthase in brain regions leads to alterations of spontaneous behavior in rats. Male Wistar rats were treated with NO synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) at the dose of 40 mg/kg/day. After 4 weeks of L-NAME treatment, NO synthase activity was significantly decreased by 75% in the cerebellum, by 71% in the cerebral cortex and by 72% in the thoracic spinal cord. Decreased NO synthase activity in the nervous tissue was associated with decreased motor horizontal and vertical activities as well as by lowered frequency of sniffing, cleaning and defecation. It is concluded that the inhibition of NO synthase activity has a suppressive effect on spontaneous behavior of rats.
