Radioprotective action of extracellular adenosine on bone marrow cells in mice exposed to gamma rays as assayed by the micronucleus test
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Adenosine Monophosphate pharmacology MeSH
- Bone Marrow Cells drug effects radiation effects ultrastructure MeSH
- Chromosome Aberrations MeSH
- Dipyridamole pharmacology MeSH
- Erythrocytes drug effects radiation effects ultrastructure MeSH
- Drug Combinations MeSH
- Mice, Inbred Strains MeSH
- Phosphodiesterase Inhibitors pharmacology MeSH
- Micronucleus Tests MeSH
- Mice MeSH
- DNA Damage MeSH
- Radiation-Protective Agents pharmacology MeSH
- Gamma Rays MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adenosine Monophosphate MeSH
- Dipyridamole MeSH
- Drug Combinations MeSH
- Phosphodiesterase Inhibitors MeSH
- Radiation-Protective Agents MeSH
The frequency of micronucleated polychromatic erythrocytes (PCEs) in mouse bone marrow was assessed after administration of dipyridamole and/or adenosine monophosphate (AMP) to nonirradiated mice or to mice irradiated 15 min later with a sublethal dose of 6.5 Gy gamma rays. In nonirradiated mice, the administration of the drugs increased the frequency of micronucleated PCEs significantly (by 108%). In contrast, in irradiated mice, the number of radiation-induced micronucleated PCEs was significantly decreased if the mice had been pretreated with dipyridamole or AMP alone (by 24% after administration of each of the compounds) and in particular after administration of the drugs in combination (by 36%).
References provided by Crossref.org
The role of adenosine receptor agonists in regulation of hematopoiesis
