The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats
Jazyk angličtina Země Irsko Médium print
Typ dokumentu časopisecké články
PubMed
11118671
DOI
10.1016/s0300-483x(00)00322-x
PII: S0300-483X(00)00322-X
Knihovny.cz E-zdroje
- MeSH
- antagonisté muskarinových receptorů farmakologie normy MeSH
- antidota farmakologie normy MeSH
- atropin farmakologie normy MeSH
- benaktyzin farmakologie normy MeSH
- biperiden farmakologie normy MeSH
- chemické bojové látky toxicita MeSH
- cholinesterasové inhibitory toxicita MeSH
- elektrokardiografie MeSH
- krevní tlak MeSH
- krysa rodu Rattus MeSH
- oximy MeSH
- pyridinové sloučeniny farmakologie normy MeSH
- reaktivátory cholinesterázy farmakologie normy MeSH
- skopolamin farmakologie normy MeSH
- soman toxicita MeSH
- srdeční frekvence MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antagonisté muskarinových receptorů MeSH
- antidota MeSH
- asoxime chloride MeSH Prohlížeč
- atropin MeSH
- benaktyzin MeSH
- biperiden MeSH
- chemické bojové látky MeSH
- cholinesterasové inhibitory MeSH
- oximy MeSH
- pyridinové sloučeniny MeSH
- reaktivátory cholinesterázy MeSH
- skopolamin MeSH
- soman MeSH
The influence of some anticholinergic drugs (atropine, benactyzine, biperiden, scopolamine) on the efficacy of antidotal treatment to eliminate soman (O-pinacolyl methylphosphonofluoridate)-induced disturbance of respiration and circulation and to protect experimental animals poisoned with supralethal dose of soman (1.5 x LD(50)) was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. While the oxime HI-6 in combination with atropine prevented soman-induced changes in monitored physiological parameters insufficiently and very shortly, the combination of HI-6 with benactyzine or biperiden is able to prevent soman-induced alteration of respiration and circulation much more longer. Nevertheless, only rats treated with HI-6 in combination with scopolamine were fully protected against the lethal toxic effects of soman within 2 h following soman challenge. Our findings confirm that anticholinergic drugs with the strong central antimuscarinic activity, such as benactyzine, biperiden and especially scopolamine, seem to be more effective adjuncts to HI-6 treatment of severe acute soman-induced poisoning than atropine.
Citace poskytuje Crossref.org
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