The influence of anticholinergic drug selection on the efficacy of antidotal treatment of soman-poisoned rats
Language English Country Ireland Media print
Document type Journal Article
PubMed
11118671
DOI
10.1016/s0300-483x(00)00322-x
PII: S0300-483X(00)00322-X
Knihovny.cz E-resources
- MeSH
- Muscarinic Antagonists pharmacology standards MeSH
- Antidotes pharmacology standards MeSH
- Atropine pharmacology standards MeSH
- Benactyzine pharmacology standards MeSH
- Biperiden pharmacology standards MeSH
- Chemical Warfare Agents toxicity MeSH
- Cholinesterase Inhibitors toxicity MeSH
- Electrocardiography MeSH
- Blood Pressure MeSH
- Rats MeSH
- Oximes MeSH
- Pyridinium Compounds pharmacology standards MeSH
- Cholinesterase Reactivators pharmacology standards MeSH
- Scopolamine pharmacology standards MeSH
- Soman toxicity MeSH
- Heart Rate MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Muscarinic Antagonists MeSH
- Antidotes MeSH
- asoxime chloride MeSH Browser
- Atropine MeSH
- Benactyzine MeSH
- Biperiden MeSH
- Chemical Warfare Agents MeSH
- Cholinesterase Inhibitors MeSH
- Oximes MeSH
- Pyridinium Compounds MeSH
- Cholinesterase Reactivators MeSH
- Scopolamine MeSH
- Soman MeSH
The influence of some anticholinergic drugs (atropine, benactyzine, biperiden, scopolamine) on the efficacy of antidotal treatment to eliminate soman (O-pinacolyl methylphosphonofluoridate)-induced disturbance of respiration and circulation and to protect experimental animals poisoned with supralethal dose of soman (1.5 x LD(50)) was investigated in a rat model with on-line monitoring of respiratory and circulatory parameters. While the oxime HI-6 in combination with atropine prevented soman-induced changes in monitored physiological parameters insufficiently and very shortly, the combination of HI-6 with benactyzine or biperiden is able to prevent soman-induced alteration of respiration and circulation much more longer. Nevertheless, only rats treated with HI-6 in combination with scopolamine were fully protected against the lethal toxic effects of soman within 2 h following soman challenge. Our findings confirm that anticholinergic drugs with the strong central antimuscarinic activity, such as benactyzine, biperiden and especially scopolamine, seem to be more effective adjuncts to HI-6 treatment of severe acute soman-induced poisoning than atropine.
References provided by Crossref.org
Anti-Parkinson Drug Biperiden Inhibits Enzyme Acetylcholinesterase
