CD8+ T lymphocytes protect SCID mice against Encephalitozoon cuniculi infection
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11336749
DOI
10.1016/s0020-7519(01)00134-5
PII: S0020751901001345
Knihovny.cz E-resources
- MeSH
- CD8-Positive T-Lymphocytes immunology MeSH
- Cytotoxicity, Immunologic MeSH
- Encephalitozoon cuniculi MeSH
- Encephalitozoonosis immunology MeSH
- Phenotype MeSH
- Mice, Inbred BALB C MeSH
- Mice, SCID MeSH
- Mice MeSH
- Adoptive Transfer MeSH
- Spleen immunology MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Microsporidia are obligate intracellular parasites that cause opportunistic infections in immunocompromised patients. The role of two main T cell subsets in anti-microsporidial immunity has been studied using an Encephalitozoon cuniculi-severe combined immunodeficient (SCID) mouse model. Whereas SCID mice reconstituted with CD4+ T lymphocyte-depleted naive BALB/c splenocytes resolved the infection, adoptive transfer of CD8+ T cell-depleted splenocytes failed to protect the animals against a lethal E. cuniculi infection. Splenocytes from E. cuniculi-immune mice specifically killed syngeneic infected macrophages in a short-term 51Cr-release assay. These results suggest the crucial role of cytotoxic T lymphocytes in the protection against E. cuniculi infection.
References provided by Crossref.org
Chronic Infections in Mammals Due to Microsporidia
