Anticancer drugs as inducers of thermotolerance in yeast
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
11347257
DOI
10.1007/bf02817558
Knihovny.cz E-zdroje
- MeSH
- bleomycin farmakologie MeSH
- cisplatina farmakologie MeSH
- fluoruracil farmakologie MeSH
- irinotekan MeSH
- kamptothecin analogy a deriváty farmakologie MeSH
- methotrexát farmakologie MeSH
- mitomycin farmakologie MeSH
- protinádorové látky farmakologie MeSH
- Saccharomyces účinky léků fyziologie MeSH
- vysoká teplota * MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- bleomycin MeSH
- cisplatina MeSH
- fluoruracil MeSH
- irinotekan MeSH
- kamptothecin MeSH
- methotrexát MeSH
- mitomycin MeSH
- protinádorové látky MeSH
Yeast cell viability was evaluated microscopically following exposure to heat shock for 30 min at 53 degrees C. The cells were previously grown in the presence of potential stressors (anticancer drugs; e.g., 5-fluorouracil, methotrexate, cisplatin, bleomycin, mitomycin-C and camptothecin-11). The induction of thermotolerance was documented by significantly increased viability after heat shock. This effect, which was reversed by cycloheximide, was comparable to that observed following exposure to a mild heat stress. These data demonstrate that pretreatment with sub-toxic concentrations of some of the clinically used antineoplastic agents conferres thermotolerance to yeast, possibly through the synthesis of protein components.
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Effect of the Hsp90 modulators on the heat-shock response in eukaryotic cells
Induction of morphological alterations by antineoplastic agents in yeast
