Irinotecan [irinotekan]
topical
54
- Terms
-
7-ethyl-10-hydroxycamptothecin
aktivní metabolit irinotekanu
Camptosar
CPT-11
irinotecan
irinotekan hydrochlorid
irinotekan hydrochlorid trihydrát
irinotekan-hydrochlorid
SN-38
-
7-Ethyl-10-hydroxycamptothecin
Camptosar
Camptothecin-11
CPT 11
CPT-11
Irinotecan Hydrochloride
Irrinotecan
NK012 Compound
SN 38
SN 38 11
SN-38
SN-38-11
Persistent link
https://www.medvik.cz/link/D000077146
Definition
A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.
- DUI
- D000077146 MeSH Browser
- CUI
- M0147530
- CAS
- (1,4'-Bipiperidine)-1'-carboxylic acid, (4S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinolin-9-yl ester
- History note
- 2019 (1987)
- Public note
- 2019; IRINOTECAN was indexed under CAMPTOTHECIN 1987-2018
Allowable subheadings
- AD
- administration & dosage 10
- AE
- adverse effects 4
- AG
- agonists
- AA
- analogs & derivatives
- AN
- analysis
- AI
- antagonists & inhibitors
- BL
- blood
- CF
- cerebrospinal fluid
- CS
- chemical synthesis
- CH
- chemistry
- CL
- classification 1
- EC
- economics
- HI
- history
- IM
- immunology
- IP
- isolation & purification
- ME
- metabolism
- PK
- pharmacokinetics 1
- PD
- pharmacology 18
- PO
- poisoning
- RE
- radiation effects
- ST
- standards
- SD
- supply & distribution
- TU
- therapeutic use 32
- TO
- toxicity
- UR
- urine
...
Occurrences in Medvik records
D
Chemicals and Drugs