Anticancer drugs as inducers of thermotolerance in yeast
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
11347257
DOI
10.1007/bf02817558
Knihovny.cz E-resources
- MeSH
- Bleomycin pharmacology MeSH
- Cisplatin pharmacology MeSH
- Fluorouracil pharmacology MeSH
- Irinotecan MeSH
- Camptothecin analogs & derivatives pharmacology MeSH
- Methotrexate pharmacology MeSH
- Mitomycin pharmacology MeSH
- Antineoplastic Agents pharmacology MeSH
- Saccharomyces drug effects physiology MeSH
- Hot Temperature * MeSH
- Dose-Response Relationship, Drug MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Bleomycin MeSH
- Cisplatin MeSH
- Fluorouracil MeSH
- Irinotecan MeSH
- Camptothecin MeSH
- Methotrexate MeSH
- Mitomycin MeSH
- Antineoplastic Agents MeSH
Yeast cell viability was evaluated microscopically following exposure to heat shock for 30 min at 53 degrees C. The cells were previously grown in the presence of potential stressors (anticancer drugs; e.g., 5-fluorouracil, methotrexate, cisplatin, bleomycin, mitomycin-C and camptothecin-11). The induction of thermotolerance was documented by significantly increased viability after heat shock. This effect, which was reversed by cycloheximide, was comparable to that observed following exposure to a mild heat stress. These data demonstrate that pretreatment with sub-toxic concentrations of some of the clinically used antineoplastic agents conferres thermotolerance to yeast, possibly through the synthesis of protein components.
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Effect of the Hsp90 modulators on the heat-shock response in eukaryotic cells
Induction of morphological alterations by antineoplastic agents in yeast
